Reminder: Alkylation of Amines Is Rarely The Answer.
Is there another way to do it?In addition, a cheaper, easy-to-handle, and environmentally friendly reducing reagent such as polymethylhydrosiloxane (pmhs) in place of Et3SiH was also useful.Lett., 2006, 8, 741-744.An efficient method for the direct reductive alkylation of hydrazine derivatives with -picoline-borane provided various N -alkylhydrazine derivatives upon fine-tuning of the substrates and the reagent equivalency in a one-pot manner.An example of the quantitative TLC binding studies using neoglycolipids is shown in Fig.An efficient methodology for the reductive alkylation of secondary amines with aldehydes and Et3SiH using an iridium complex as a catalyst has been developed.An oxidation/imine-iminium formation/reduction cascade using tempo-baib-HEH-Brønsted acid catalysis in dmpu as solvent enables a mild and atom-economical nonepimerizing chemo- and enantioselective N-alkylating procedure of amines with alcohols.This process is called reductive amination.
We used the same binding carbohydrates in the form of glycosphingolipids and different neoglycolipids carrying different lipid parts and could in this way eliminate the possible influence of lipid parts on the binding.
Alkenes or phenyl groups) or between nitrogen and sp-hybridized carbons (e.g.Brønsted acid catalysis enables highly efficient, regioselective, and enantioselective transfer hydrogenation of -keto ketimines and reductive amination of diketones.Its very helpful to be able to think backwards from an amine product to what the starting materials look like.One must resort to alternative techniques.3 for the pentasaccharide GlcA3Gal4GlcNAc3Gal4Glc.On code reduction bruneau mobilier the other hand neoglycolipids containing GlcNAc or Gal6 in the same position turned out to be excellent binding molecules thus showing that a single glycosidic bond in the core chain may be a decisive factor of the interaction.